modified lbr Search Results


lbr  (Abcam)
96
Abcam lbr
<t>LBR</t> is a key downstream gene of METTL14. (a) Schematic diagram showing the screening criterion for METTL14 targets. Venn diagram of all the possible overlapping transcripts in nine comparison groups sequenced together, showing reduced abundance with senescence and filtering for a significant FDR < 0.15. RNA-seq data was acquired from GEO datasets (GSE130727). RT-qPCR was performed in CCD18-Co with METTL14 knockdown to validate the overlapped genes. The LBR was consistent among 19 genes. FBL : fibrillarin; ITPRIP : inositol 1,4,5-trisphosphate receptor interacting protein; LBR : lamin B receptor; FAM129A : family with sequence similarity 129 member A; MCUB: mitochondrial calcium uniporter dominant negative subunit beta; SSRP1: structure specific recognition protein 1; TMSB15A : thymosin beta 15A; HIST1H1D : H1.3 linker histone, cluster member; CDCA7L: cell division cycle associated 7 like; CBS : cystathionine beta-synthase; HIST1H1A: H1.1 linker histone, cluster member; HIST1H1E : H1.4 linker histone, cluster member; PTMA : prothymosin alpha; ANP32B : acidic nuclear phosphoprotein 32 family member B; CBX2 : chromobox 2; HIST2H2AB: histone cluster 2 H2A family member B; PARP1 : poly(ADP-ribose) polymerase 1; H3FF : H3 clustered histone 11; H2BH : H2B clustered histone 9. (b) The expression of LBR following METTL14 knockdown or overexpression was evaluated by western blotting. (c) Prediction of the specific m 6 A methylation loci of LBR using the SRAMP website. (d) METTL14-silenced cells were treated with actinomycin D and harvested at 0, 2, or 4 h. RNA decay rates were determined to estimate the stability of LBR mRNA (normalized to the expression at 0 h). Data are expressed as mean ± SD of three independent biological experiments. Two-way ANOVA analysis. ∗∗ p < 0.01. (e) m 6 A modification of LBR was detected by MeRIP-qPCR analysis using anti-IgG and anti-m 6 <t>A</t> <t>antibodies.</t> Relative m 6 A enrichment of LBR mRNA for each IP group was normalized to input. Data are expressed as mean ± SD of three independent biological experiments. One-way ANOVA followed by Tukey's test. ∗∗ p < 0.01.
Lbr, supplied by Abcam, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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comparative) diene polymer 10 (kuraprene lbr-305  (Kuraray Co Ltd)
90
Kuraray Co Ltd comparative) diene polymer 10 (kuraprene lbr-305
<t>LBR</t> is a key downstream gene of METTL14. (a) Schematic diagram showing the screening criterion for METTL14 targets. Venn diagram of all the possible overlapping transcripts in nine comparison groups sequenced together, showing reduced abundance with senescence and filtering for a significant FDR < 0.15. RNA-seq data was acquired from GEO datasets (GSE130727). RT-qPCR was performed in CCD18-Co with METTL14 knockdown to validate the overlapped genes. The LBR was consistent among 19 genes. FBL : fibrillarin; ITPRIP : inositol 1,4,5-trisphosphate receptor interacting protein; LBR : lamin B receptor; FAM129A : family with sequence similarity 129 member A; MCUB: mitochondrial calcium uniporter dominant negative subunit beta; SSRP1: structure specific recognition protein 1; TMSB15A : thymosin beta 15A; HIST1H1D : H1.3 linker histone, cluster member; CDCA7L: cell division cycle associated 7 like; CBS : cystathionine beta-synthase; HIST1H1A: H1.1 linker histone, cluster member; HIST1H1E : H1.4 linker histone, cluster member; PTMA : prothymosin alpha; ANP32B : acidic nuclear phosphoprotein 32 family member B; CBX2 : chromobox 2; HIST2H2AB: histone cluster 2 H2A family member B; PARP1 : poly(ADP-ribose) polymerase 1; H3FF : H3 clustered histone 11; H2BH : H2B clustered histone 9. (b) The expression of LBR following METTL14 knockdown or overexpression was evaluated by western blotting. (c) Prediction of the specific m 6 A methylation loci of LBR using the SRAMP website. (d) METTL14-silenced cells were treated with actinomycin D and harvested at 0, 2, or 4 h. RNA decay rates were determined to estimate the stability of LBR mRNA (normalized to the expression at 0 h). Data are expressed as mean ± SD of three independent biological experiments. Two-way ANOVA analysis. ∗∗ p < 0.01. (e) m 6 A modification of LBR was detected by MeRIP-qPCR analysis using anti-IgG and anti-m 6 <t>A</t> <t>antibodies.</t> Relative m 6 A enrichment of LBR mRNA for each IP group was normalized to input. Data are expressed as mean ± SD of three independent biological experiments. One-way ANOVA followed by Tukey's test. ∗∗ p < 0.01.
Comparative) Diene Polymer 10 (Kuraprene Lbr 305, supplied by Kuraray Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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anti lamin b  (Boster Bio)
94
Boster Bio anti lamin b
<t>LBR</t> is a key downstream gene of METTL14. (a) Schematic diagram showing the screening criterion for METTL14 targets. Venn diagram of all the possible overlapping transcripts in nine comparison groups sequenced together, showing reduced abundance with senescence and filtering for a significant FDR < 0.15. RNA-seq data was acquired from GEO datasets (GSE130727). RT-qPCR was performed in CCD18-Co with METTL14 knockdown to validate the overlapped genes. The LBR was consistent among 19 genes. FBL : fibrillarin; ITPRIP : inositol 1,4,5-trisphosphate receptor interacting protein; LBR : lamin B receptor; FAM129A : family with sequence similarity 129 member A; MCUB: mitochondrial calcium uniporter dominant negative subunit beta; SSRP1: structure specific recognition protein 1; TMSB15A : thymosin beta 15A; HIST1H1D : H1.3 linker histone, cluster member; CDCA7L: cell division cycle associated 7 like; CBS : cystathionine beta-synthase; HIST1H1A: H1.1 linker histone, cluster member; HIST1H1E : H1.4 linker histone, cluster member; PTMA : prothymosin alpha; ANP32B : acidic nuclear phosphoprotein 32 family member B; CBX2 : chromobox 2; HIST2H2AB: histone cluster 2 H2A family member B; PARP1 : poly(ADP-ribose) polymerase 1; H3FF : H3 clustered histone 11; H2BH : H2B clustered histone 9. (b) The expression of LBR following METTL14 knockdown or overexpression was evaluated by western blotting. (c) Prediction of the specific m 6 A methylation loci of LBR using the SRAMP website. (d) METTL14-silenced cells were treated with actinomycin D and harvested at 0, 2, or 4 h. RNA decay rates were determined to estimate the stability of LBR mRNA (normalized to the expression at 0 h). Data are expressed as mean ± SD of three independent biological experiments. Two-way ANOVA analysis. ∗∗ p < 0.01. (e) m 6 A modification of LBR was detected by MeRIP-qPCR analysis using anti-IgG and anti-m 6 <t>A</t> <t>antibodies.</t> Relative m 6 A enrichment of LBR mRNA for each IP group was normalized to input. Data are expressed as mean ± SD of three independent biological experiments. One-way ANOVA followed by Tukey's test. ∗∗ p < 0.01.
Anti Lamin B, supplied by Boster Bio, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human chmp1b recombinant protein  (Boster Bio)
N/A
Human CHMP1B Recombinant Protein expressed in E. coli with His-tag. Sequence domain: 1-199aa. Application(s): SDS-PAGE.
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Image Search Results


LBR is a key downstream gene of METTL14. (a) Schematic diagram showing the screening criterion for METTL14 targets. Venn diagram of all the possible overlapping transcripts in nine comparison groups sequenced together, showing reduced abundance with senescence and filtering for a significant FDR < 0.15. RNA-seq data was acquired from GEO datasets (GSE130727). RT-qPCR was performed in CCD18-Co with METTL14 knockdown to validate the overlapped genes. The LBR was consistent among 19 genes. FBL : fibrillarin; ITPRIP : inositol 1,4,5-trisphosphate receptor interacting protein; LBR : lamin B receptor; FAM129A : family with sequence similarity 129 member A; MCUB: mitochondrial calcium uniporter dominant negative subunit beta; SSRP1: structure specific recognition protein 1; TMSB15A : thymosin beta 15A; HIST1H1D : H1.3 linker histone, cluster member; CDCA7L: cell division cycle associated 7 like; CBS : cystathionine beta-synthase; HIST1H1A: H1.1 linker histone, cluster member; HIST1H1E : H1.4 linker histone, cluster member; PTMA : prothymosin alpha; ANP32B : acidic nuclear phosphoprotein 32 family member B; CBX2 : chromobox 2; HIST2H2AB: histone cluster 2 H2A family member B; PARP1 : poly(ADP-ribose) polymerase 1; H3FF : H3 clustered histone 11; H2BH : H2B clustered histone 9. (b) The expression of LBR following METTL14 knockdown or overexpression was evaluated by western blotting. (c) Prediction of the specific m 6 A methylation loci of LBR using the SRAMP website. (d) METTL14-silenced cells were treated with actinomycin D and harvested at 0, 2, or 4 h. RNA decay rates were determined to estimate the stability of LBR mRNA (normalized to the expression at 0 h). Data are expressed as mean ± SD of three independent biological experiments. Two-way ANOVA analysis. ∗∗ p < 0.01. (e) m 6 A modification of LBR was detected by MeRIP-qPCR analysis using anti-IgG and anti-m 6 A antibodies. Relative m 6 A enrichment of LBR mRNA for each IP group was normalized to input. Data are expressed as mean ± SD of three independent biological experiments. One-way ANOVA followed by Tukey's test. ∗∗ p < 0.01.

Journal: Oxidative Medicine and Cellular Longevity

Article Title: METTL14 Regulates Intestine Cellular Senescence through m 6 A Modification of Lamin B Receptor

doi: 10.1155/2022/9096436

Figure Lengend Snippet: LBR is a key downstream gene of METTL14. (a) Schematic diagram showing the screening criterion for METTL14 targets. Venn diagram of all the possible overlapping transcripts in nine comparison groups sequenced together, showing reduced abundance with senescence and filtering for a significant FDR < 0.15. RNA-seq data was acquired from GEO datasets (GSE130727). RT-qPCR was performed in CCD18-Co with METTL14 knockdown to validate the overlapped genes. The LBR was consistent among 19 genes. FBL : fibrillarin; ITPRIP : inositol 1,4,5-trisphosphate receptor interacting protein; LBR : lamin B receptor; FAM129A : family with sequence similarity 129 member A; MCUB: mitochondrial calcium uniporter dominant negative subunit beta; SSRP1: structure specific recognition protein 1; TMSB15A : thymosin beta 15A; HIST1H1D : H1.3 linker histone, cluster member; CDCA7L: cell division cycle associated 7 like; CBS : cystathionine beta-synthase; HIST1H1A: H1.1 linker histone, cluster member; HIST1H1E : H1.4 linker histone, cluster member; PTMA : prothymosin alpha; ANP32B : acidic nuclear phosphoprotein 32 family member B; CBX2 : chromobox 2; HIST2H2AB: histone cluster 2 H2A family member B; PARP1 : poly(ADP-ribose) polymerase 1; H3FF : H3 clustered histone 11; H2BH : H2B clustered histone 9. (b) The expression of LBR following METTL14 knockdown or overexpression was evaluated by western blotting. (c) Prediction of the specific m 6 A methylation loci of LBR using the SRAMP website. (d) METTL14-silenced cells were treated with actinomycin D and harvested at 0, 2, or 4 h. RNA decay rates were determined to estimate the stability of LBR mRNA (normalized to the expression at 0 h). Data are expressed as mean ± SD of three independent biological experiments. Two-way ANOVA analysis. ∗∗ p < 0.01. (e) m 6 A modification of LBR was detected by MeRIP-qPCR analysis using anti-IgG and anti-m 6 A antibodies. Relative m 6 A enrichment of LBR mRNA for each IP group was normalized to input. Data are expressed as mean ± SD of three independent biological experiments. One-way ANOVA followed by Tukey's test. ∗∗ p < 0.01.

Article Snippet: After blocking with 5% BSA solutions for 2 h at room temperature, membranes were incubated using the following antibodies: LBR (diluted 1 : 500, ab32535; Abcam, Cambridge, UK), p53 (diluted 1 : 1000, ab26; Abcam), p21 (diluted 1 : 1000, ab109199; Abcam), p16 (diluted 1 : 1000, ET1602-9; HUABIO, Hangzhou, China), METTL14 (diluted 1 : 1000, 26158-1-AP; Proteintech, Wuhan, China), WTAP (diluted 1 : 1000, 60188-1-Ig; Proteintech), ALKBH5 (diluted 1 : 1000, 16837-1-AP; Proteintech), YTHDC1 (diluted 1 : 1000, A7318; ABclonal, Wuhan, China), YTHDC2 (diluted 1 : 1000, A15004; ABclonal), METTL3 (diluted 1 : 1000, db318; Diagbio, Hangzhou, China), and β -actin (as the loading control) (diluted 1 : 1000, 3700; CST, Danvers, USA) at 4°C overnight.

Techniques: RNA Sequencing Assay, Quantitative RT-PCR, Sequencing, Dominant Negative Mutation, Expressing, Over Expression, Western Blot, Methylation, Modification